Antiproliferative Phenanthrenes from Juncus tenuis: Isolation and Diversity-Oriented Semisynthetic Modification

Semisynthetic modification of antibiotic lincomycin.

as celesticetin2) (2) have been prepared3) by synthetic anc microbiological transformation, involving modificatior of the parent antibiotics both at the sugar moiety anc the amino acid side-chain (Fig. 1). Of these new derivatives 7(S)-chloro-7-deoxylincomycin4) (3, cleocin, clindamycin) is one of the most important, possessing mon pronounced and wider spectrum of antibiotic activity, a* well a...

Isolation and Structure Elucidation of Antiproliferative Agents from Madagascar Rainforests

Bioactivity-guided isolation of antiproliferative compounds from Centaurea carduiformis DC

In this study, antiproliferative activity of methanol extract of Centaura carduiformis DC. subsp. carduiformis var. carduiformis DC (CC) was examined against Vero, HeLa and C6 cell lines in 1000 and 500 mg/mL concentrations using the BrdU ELISA assay. The CC root (CCR) has the most effective antiproliferative activity. The root extract was fractionated using various solvent and determined antip...

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

Betulinic acid (BA), a pentacyclic triterpene isolated from birch bark and other plants, selectively inhibits the growth of human cancer cell lines. However, the poor potency of BA hinders its clinical development, despite a lack of toxicity in animal studies even at high concentrations. Here, we describe six BA derivatives that are markedly more potent than BA for inhibiting inducible nitric o...

Bioassay - guided Isolation of Antiproliferative Triterpenoids